Laura Marchetti is a researcher in molecular biology at the Pharmacy Department of University of Pisa (UNIPI). She received her Ph.D. in molecular biology from Scuola Normale Superiore of Pisa in 2010, and prior to joining UNIPI, she was a post-doctoral fellow first at Scuola Normale Superiore and then at the Italian Institute of Technology. Dr Marchetti is interested in studying molecular interactions (both protein-protein and nucleic acid-protein interactions), and how these are altered in pathological conditions prompted e.g. by the presence of mutations in their sequence. She has already exploited the advantages of traditional computational methods to analyze molecular interactions with high spatio-temporal resolution, as well as to predict the impact of specific mutations in a protein sequence. Her contribution to this project will be defining which biological problems can be realistically tackled by a quantum computing approach.
Relevant Publications
Convertino D, Fabbri F, Mishra N, Mainardi M, Cappello V, Testa G, Capsoni S, Albertazzi L, Luin S, Marchetti L, Coletti C, “Graphene Promotes Axon Elongation through Local Stall of Nerve Growth Factor Signaling Endosomes”, Nano Letters, 2020, 20, 5, 3633–3641.
doi: 10.1021/acs.nanolett.0c00571
Amodeo R, Nifosì R, Giacomelli C, Ravelli C, La Rosa L, Callegari A, Trincavelli ML, Mitola S, Luin S, Marchetti L, “Molecular insight on the altered membrane trafficking of TrkA kinase dead mutants”, BBA-Molecular Cell Research, 2019 Nov 21;1867(2):118614.
doi: 10.1016/j.bbamcr.2019.118614
Marchetti L, Bonsignore F, Gobbo F, Amodeo R, Calvello M, Jacob A, Signore G, Schirripa Spagnolo C, Porciani D, Mainardi M, Beltram F, Luin S, Cattaneo A, “Fast-diffusing p75NTR monomers support apoptosis and growth cone collapse by neurotrophin ligands”, PNAS 2019 Sept 12, 2019, doi: 10.1073/pnas.1902790116.
doi: 10.1073/pnas.1902790116.
Yan R, Yalinca H, Paoletti F, Gobbo F, Marchetti L, Kuzmanic A, Lamba D, Gervasio FL, Konarev PV, Cattaneo A, Pastore A, “The structure of the Pro-domain of mouse proNGF in contact with the NGF domain”, Structure 2018 Oct 19.
doi: 10.1016/j.str.2018.09.013.
Gobbo F, Marchetti L, Jacob A, Pinto B, Binini N, Pecoraro Bisogni F, Alia C, Luin S, Caleo M, Fellin T, Cancedda L, Cattaneo A., “Activity-dependent expression of Channelrhodopsin at neuronal synapses”, Nat Commun, 2017 Nov 20;8(1):1629.
doi: 10.1038/s41467-017-01699-7
Cappello V, Marchetti L, Parlanti P, Landi S, Tonazzini I, Cecchini M, Piazza V, Gemmi M, “Ultrastructural Characterization of the Lower Motor System in a Mouse Model of Krabbe Disease”, Scientific Reports 6(1), Dec 2016
doi: 10.1038/s41598-016-0001-8